ARTICOLI SCIENTIFICI

Per maggiori informazioni consultate le seguenti pubblicazioni scientifiche.

Buono R, Longo VD. Starvation, Stress Resistance, and Cancer. Trends in endocrinology and metabolism: TEM. 2018;29(4):271-80. doi: 10.1016/j.tem.2018.01.008. PubMed PMID: 29463451. PDF
Wei, M., et al., Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med, 2017. 9(377). PDF
Nashiro, K., et al., Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci, 2017. 37(7): p. 1696-1707. PDF
Lee, A.S., et al., Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep, 2017. 7: p. 40919. PDF
Hine, C., et al., Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab, 2017. 25(6): p. 1320-1333 e5. PDF
Brandhorst, S., et al., Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev, 2017. PDF
Vernieri, C., et al., Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov, 2016. 6(12): p. 1315-1333. PDF
Song, M., et al., Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med, 2016. 176(10): p. 1453-1463. PDF
Mattson, M.P., V.D. Longo, and M. Harvie, Impact of intermittent fasting on health and disease processes. Ageing Res Rev, 2016. PDF
Dorff, T.B., et al., Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer, 2016. 16(1): p. 360. PDF
Di Biase, S. and V.D. Longo, Fasting-induced differential stress sensitization in cancer treatment. Mol Cell Oncol, 2016. 3(3): p. e1117701. PDF
Di Biase, S., et al., Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell, 2016. 30(1): p. 136-46. PDF
Brandhorst, S. and V.D. Longo, Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res, 2016. 207: p. 241-66. PDF
Shim, H.S., et al., Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res, 2015. 75(6): p. 1056-67. PDF
Hirschey, M.D., et al., Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol, 2015. 35 Suppl: p. S129-50. PDF
Caffa, I., V.D. Longo, and A. Nencioni, Fasting plus tyrosine kinase inhibitors in cancer. Aging (Albany NY), 2015. 7(12): p. 1026-7. PDF
Block, K.I., et al., Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol, 2015. 35 Suppl: p. S276-304. PDF
Mattson, M.P., et al., Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A, 2014. 111(47): p. 16647-53. PDF
Longo, V.D. and M.P. Mattson, Fasting: molecular mechanisms and clinical applications. Cell Metab, 2014. 19(2): p. 181-92. PDF
Levine, M.E., et al., Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab, 2014. 19(3): p. 407-17. PDF
Cheng, C.W., et al., Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell, 2014. 14(6): p. 810-23. PDF
Nencioni, A., et al., Autophagy in blood cancers: biological role and therapeutic implications. Haematologica, 2013. 98(9): p. 1335-43. PDF
Brandhorst, S., et al., Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol, 2013. 48(10): p. 1120-8. PDF
Balasubramanian, P. and V.D. Longo, Aging, nutrient signaling, hematopoietic senescence, and cancer. Crit Rev Oncog, 2013. 18(6): p. 559-71. PDF
Safdie, F., et al., Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One, 2012. 7(9): p. e44603. PDF
Pfaffenbach, K.T., et al., GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol, 2012. 227(12): p. 3803-11. PDF
Lee, C., L. Raffaghello, and V.D. Longo, Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat, 2012. 15(1-2): p. 114-22. PDF
Fontana, L., M. Vinciguerra, and V.D. Longo, Growth factors, nutrient signaling, and cardiovascular aging. Circ Res, 2012. 110(8): p. 1139-50. PDF
Lee, C. and V.D. Longo, Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene, 2011. 30(30): p. 3305-16. PDF
Longo, V.D. and L. Fontana, Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci, 2010. 31(2): p. 89-98. PDF
Lee, C., et al., Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res, 2010. 70(4): p. 1564-72. PDF
Blagosklonny, M.V., et al., Impact papers on aging in 2009. Aging (Albany NY), 2010. 2(3): p. 111-21. PDF
Safdie, F.M., et al., Fasting and cancer treatment in humans: A case series report. Aging (Albany NY), 2009. 1(12): p. 988-1007. PDF
Raffaghello, L., et al., Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A, 2008. 105(24): p. 8215-20. PDF
Madia, F., et al., Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol, 2008. 180(1): p. 67-81. PDF
Longo, V.D., M.R. Lieber, and J. Vijg, Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol, 2008. 9(11): p. 903-10. PDF

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ARTICOLI SCIENTIFICI

Buono R, Longo VD. Starvation, Stress Resistance, and Cancer. Trends in endocrinology and metabolism: TEM. 2018;29(4):271-80. doi: 10.1016/j.tem.2018.01.008. PubMed PMID: 29463451. PDF

Wei, M., et al., Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med, 2017. 9(377). PDF

Nashiro, K., et al., Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci, 2017. 37(7): p. 1696-1707. PDF

Lee, A.S., et al., Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep, 2017. 7: p. 40919. PDF

Hine, C., et al., Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab, 2017. 25(6): p. 1320-1333 e5. PDF

Brandhorst, S., et al., Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev, 2017. PDF

Vernieri, C., et al., Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov, 2016. 6(12): p. 1315-1333. PDF

Song, M., et al., Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med, 2016. 176(10): p. 1453-1463. PDF

Mattson, M.P., V.D. Longo, and M. Harvie, Impact of intermittent fasting on health and disease processes. Ageing Res Rev, 2016. PDF

Dorff, T.B., et al., Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer, 2016. 16(1): p. 360. PDF

Di Biase, S. and V.D. Longo, Fasting-induced differential stress sensitization in cancer treatment. Mol Cell Oncol, 2016. 3(3): p. e1117701. PDF

Di Biase, S., et al., Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell, 2016. 30(1): p. 136-46. PDF

Brandhorst, S. and V.D. Longo, Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res, 2016. 207: p. 241-66. PDF

Shim, H.S., et al., Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res, 2015. 75(6): p. 1056-67. PDF

Hirschey, M.D., et al., Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol, 2015. 35 Suppl: p. S129-50. PDF

Caffa, I., V.D. Longo, and A. Nencioni, Fasting plus tyrosine kinase inhibitors in cancer. Aging (Albany NY), 2015. 7(12): p. 1026-7. PDF

Block, K.I., et al., Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol, 2015. 35 Suppl: p. S276-304. PDF

Mattson, M.P., et al., Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A, 2014. 111(47): p. 16647-53. PDF

Longo, V.D. and M.P. Mattson, Fasting: molecular mechanisms and clinical applications. Cell Metab, 2014. 19(2): p. 181-92. PDF

Levine, M.E., et al., Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab, 2014. 19(3): p. 407-17. PDF

Cheng, C.W., et al., Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell, 2014. 14(6): p. 810-23. PDF

Nencioni, A., et al., Autophagy in blood cancers: biological role and therapeutic implications. Haematologica, 2013. 98(9): p. 1335-43. PDF

Brandhorst, S., et al., Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol, 2013. 48(10): p. 1120-8. PDF

Balasubramanian, P. and V.D. Longo, Aging, nutrient signaling, hematopoietic senescence, and cancer. Crit Rev Oncog, 2013. 18(6): p. 559-71. PDF

Safdie, F., et al., Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One, 2012. 7(9): p. e44603. PDF

Pfaffenbach, K.T., et al., GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol, 2012. 227(12): p. 3803-11. PDF

Lee, C., L. Raffaghello, and V.D. Longo, Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat, 2012. 15(1-2): p. 114-22. PDF

Fontana, L., M. Vinciguerra, and V.D. Longo, Growth factors, nutrient signaling, and cardiovascular aging. Circ Res, 2012. 110(8): p. 1139-50. PDF

Lee, C. and V.D. Longo, Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene, 2011. 30(30): p. 3305-16. PDF

Longo, V.D. and L. Fontana, Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci, 2010. 31(2): p. 89-98. PDF

Lee, C., et al., Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res, 2010. 70(4): p. 1564-72. PDF

Blagosklonny, M.V., et al., Impact papers on aging in 2009. Aging (Albany NY), 2010. 2(3): p. 111-21. PDF

Safdie, F.M., et al., Fasting and cancer treatment in humans: A case series report. Aging (Albany NY), 2009. 1(12): p. 988-1007. PDF

Raffaghello, L., et al., Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A, 2008. 105(24): p. 8215-20. PDF

Madia, F., et al., Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol, 2008. 180(1): p. 67-81. PDF

Longo, V.D., M.R. Lieber, and J. Vijg, Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol, 2008. 9(11): p. 903-10. PDF

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